Anti-TMEM104 Antibody Picoband® fluoro594 Vervoeging

Transmembrane protein 104 (TMEM104) is a protein that in humans is encoded by the TMEM104 gene. Predicted to be integral component of membrane.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

TMEM104

54868

Q8NE00

Human

No cross-reactivity with other proteins.

E.coli-derived human TMEM104 recombinant protein (Position: D88-D448) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Shi, P. , Guo, Y. , Su, Y. , Zhu, M. , & Huang, J. . (2020) . Sumoylation of ddx39a alters binding and export of antiviral transcripts to control innate immunity. The Journal of Immunology, 205 (1), ji2000053. 2. Huttlin, E. , Ting, L. , Bruckner, R. , Gebreab, F. , Gygi, M. , & Szpyt, J. , et al. (2015) . The bioplex network: a systematic exploration of the human interactome. Cell, 162 (2), 425-440. 3. Ota, T. , Suzuki, Y. , Nishikawa, T. , Otsuki, T. , & Sugano, S. . (2004) . Complete sequencing and characterization of 21,243 full-length human cdnas. Nature Genetics, 36 (1), 40-45.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.