Anti-TMEM129 Antibody Picoband® fluoro488 Vervoeging

Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum.

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

TMEM129

92305

A0AVI4

Human

No cross-reactivity with other proteins.

E.coli-derived human TMEM129 recombinant protein (Position: E25-R362) .

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Flow Cytometry

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Immunogen affinity purified.

Liquid

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 9/2/2014. 2. van den Boomen, D. J. H., Timms, R. T., Grice, G. L., Stagg, H. R., Skodt, K., Dougan, G., Nathan, J. A., Lehner, P. J. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. Proc. Nat. Acad. Sci. 111: 11425-11430, 2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Eva-1 homolog A, regulator of programmed cell death

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.