Anti-TMEM132B Antibody Picoband® fluoro488 Vervoeging

Predicted to be integral component of membrane.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

TMEM132B

114795

Q14DG7

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TMEM132B recombinant protein (Position: H123-M1078) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Farlow, J. L. , Hai, L. , Laura, S. , Lai, D. , Koller, D. L. , & Elizabeth, P. , et al. (2015) . Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. PLoS ONE, 10 (3), e0121104-. 2. Luis, S. P. , & Ponting, C. P. . (2018) . Tmem132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Bioinformatics (5), 721-724. 3. Winham, S. J. , Cuellar-Barboza, A. B. , Oliveros, A. , Mcelroy, S. L. , & Biernacka, J. M. . (2013) . Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in tcf7l2. Molecular Psychiatry, 19 (9), 1010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.