Anti-TMEM59 Antibody Picoband®

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene. This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants.

Boster Bio Anti-TMEM59 Antibody Picoband® catalog # A09364-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

B-cell differentiation antigen CD72; Lyb-2; CD72; CD72

TMEM59

9528

Q9BXS4

Human

No cross-reactivity with other proteins.

E.coli-derived human TMEM59 recombinant protein (Position: A37-I323) .

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

WB, Flow Cytometry, ELISA

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Plays a role in B-cell proliferation and differentiation.

1. Boada-Romero, E., Letek, M., Fleischer, A., Pallauf, K., Ramon-Barros, C., Pimentel-Muinos, F. X. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. EMBO J. 32: 566-582, 2013. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 08/19/2016. 3. Ullrich, S., Munch, A., Neumann, S., Kremmer, E., Tatzelt, J., Lichtenthaler, S. F. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 285: 20664-20674, 2010.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A09364-1

44 kDa

6

CD72 molecule

Membrane; Single-pass type II membrane protein.

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.