Anti-TMEM88 Antibody Picoband® 0,00647 Vervoeging

Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane.

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283

TMEM88

92162

Q6PEY1

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human TMEM88, which shares 86.7% amino acid (aa) sequence identity with mouse TMEM88.

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.

Flow Cytometry

Complement, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Lee, H.-J., Finkelstein, D., Li, X., Wu, D., Shi, D.-L., Zheng, J. J. Identification of transmembrane protein 88 (TMEM88) as a Dishevelled-binding protein. J. Biol. Chem. 285: 41549-41556, 2010. 2. Palpant, N. J., Pabon, L., Rabinowitz, J. S., Hadland, B. K., Stoick-Cooper, C. L., Paige, S. L., Bernstein, I. D., Moon, R. T., Murry, C. E. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development 140: 3799-3808, 2013.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

C3 and PZP like, alpha-2-macroglobulin domain containing 8

Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.