Anti-TMEM97 Antibody Picoband® 31.0550 Vervoeging

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels .

Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F

TMEM97

27346

Q5BJF2

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human TMEM97 recombinant protein (Position: A5-L141) .

Highly expressed in reproductive organs, such as testis, ovary and prostate.

Flow Cytometry

Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

1. Bartz, F., Kern, L., Erz, D., Zhu, M., Gilbert, D., Meinhof, T., Wirkner, U., Erfle, H., Muckenthaler, M., Pepperkok, R., Runz, H. Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab. 10: 63-75, 2009. 2. Kayed, H., Kleeff, J., Ding, J., Hammer, J., Giese, T., Zentgraf, H., Buchler, M. W., Friess, H. Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract. Histol. Histopath. 19: 1021-1031, 2004. 3. Malhotra, K., Luehrsen, K. R., Costello, L. L., Raich, T. J., Sim, K., Foltz, L., Davidson, S., Xu, H., Chen, A., Yamanishi, D. T., Lindemann, G. W., Cain, C. A., Madlansacay, M. R., Hashima, S. M., Pham, T. L., Mahoney, W., Schueler, P. A. Identification of differentially expressed mRNAs in human fetal liver across gestation. Nucleic Acids Res. 27: 839-847, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

SET domain bifurcated histone lysine methyltransferase 2

Nucleus. Chromosome.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.