Anti-TNF beta/LTA Antibody Picoband® fluoro594 Vervoeging

Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Nedwin et al. (1985) found that TNFA and TNFB are closely linked on chromosome 6. Study of hybrid cells made with rearranged human chromosome 6 showed that both TNFA and TNFB map to the 6p23-q12 segment.

Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; LTA; TNFB, TNFSF1

LTA

4049

P01374

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human TNF beta, different from the related mouse sequence by one amino acid.

Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .

Flow Cytometry

Biochemicals, Chemical Type, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipid Signaling, Metabolic Signaling Pathways, Metabolism, Pathways and Processes

Immunogen affinity purified.

Liquid

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

1. Parham, Peter (2005) . Chapter 6: T-cell mediated immunity. The immune system (2nd ed.) . New York: Garland Science. p. 172.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

22297 MW

No cross reactivity with other proteins.

6

Lymphotoxin-alpha

Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

Belongs to the tumor necrosis factor family.

Lymphotoxin-alpha (LT-alpha)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.