Anti-TNF Receptor II/TNFRSF1B Antibody Picoband® FLO7647 Vervoeging

Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2

TNFRSF1B

7133

P20333

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TNF Receptor II/TNFRSF1B recombinant protein (Position: L23-A189) .

Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Flow Cytometry

Cell Adhesion Proteins, ECM Proteins, Neuroscience, Sensory System, Visual System

Immunogen affinity purified.

Liquid

Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.

1. Milatovich, A.; Song, K.; Heller, R. A.; Francke, U. : Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat. Cell Molec. Genet. 17: 519-523, 1991. 2. Vielhauer, V.; Stavrakis, G.; Mayadas, T. N. : Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51561 MW

6

Bestrophin 1

Cell membrane.

Keratin, type I cytoskeletal 14

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.