Anti-TNF-receptor II/TNFRSF1B Antilichaam Picoband®

Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

Boster Bio Anti-TNF Receptor II/TNFRSF1B Antibody Picoband® catalog # A01437-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2

TNFRSF1B

7133

P20333

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TNF Receptor II/TNFRSF1B recombinant protein (Position: L23-A189) .

Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

WB, Flow Cytometry, ELISA

Cell Adhesion Proteins, ECM Proteins, Neuroscience, Sensory System, Visual System

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.

1. Milatovich, A.; Song, K.; Heller, R. A.; Francke, U. : Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat. Cell Molec. Genet. 17: 519-523, 1991. 2. Vielhauer, V.; Stavrakis, G.; Mayadas, T. N. : Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209, 2005.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A01437-1

51561 MW

75 kDa

6

Bestrophin 1

Cell membrane.

Keratin, type I cytoskeletal 14

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.