Anti-TNFAIP1 Antibody Picoband® fluoro488 Vervoeging

Tumor necrosis factor, alpha-induced protein 1 (endothelial), also known as TNFAIP1, is a human gene. The gene, present in single copy, was located in the 17q22-q23 region. This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. The protein is involved in the primary response of the endothelium to TNF.

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; hBACURD2; BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial; TNFAIP1; BACURD2, EDP1

TNFAIP1

7126

Q13829

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human TNFAIP1, identical to the related rat and mouse sequences.

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Flow Cytometry

Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR (BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. .

1. Wolf, F. W.; Marks, R. M.; Sarma, V.; Byers, M. G.; Katz, R. W.; Shows, T. B.; Dixit, V. M. : Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. J. Biol. Chem. 267: 1317-1326, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

36204 MW

No cross reactivity with other proteins.

6

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.

Belongs to the BACURD family.

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.