Anti-TNNI3K Antibody Picoband® fluoro550 Vervoeging

TNNI3 interacting kinase is a protein that in humans is encoded by the TNNI3K gene. This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology.

Max dimerization protein 1; Max dimerizer 1; Protein MAD; MXD1; MAD

TNNI3K

51086

Q59H18

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TNNI3K recombinant protein (Position: F102-Q783) .

Flow Cytometry

Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription

Immunogen affinity purified.

Liquid

Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.

1. Fan, L.-L., Huang, H., Jin, J.-Y., Li, J.-J., Chen, Y.-Q., Zhao, S.-P., Xiang, R. Whole exome sequencing identifies a novel mutation (c.333+2T-C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease. Gene 648: 63-67, 2018. 2. Lai, Z.-F., Chen, Y.-Z., Feng, L.-P., Meng, X.-M., Ding, J.-F., Wang, L.-Y., Ye, J., Li, P., Cheng, X.-S., Kitamoto, Y., Monzen, K., Komuro, I., Sakaguchi, N., Kim-Mitsuyama, S. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. Am. J. Physiol. Heart Circ. Physiol. 295: H708-H716, 2008. Note: Erratum: Am. J. Physiol. Heart Circ. Physiol. 295: H1815 only, 2008. 3. Patterson, M., Barske, L., Van Handel, B., Rau, C. D., Gan, P., Sharma, A., Parikh, S., Denholtz, M., Huang, Y., Yamaguchi, Y., Shen, H., Allayee, H., Crump, J. G., Force, T. I., Lien, C.-L., Makita, T., Lusis, A. J., Kumar, S. R., Sucov, H. M. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nature Genet. 49: 1346-1353, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

MAX dimerization protein 1

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.