Anti-tol-achtige receptor 7 TLR7 Antilichaam Picoband® fluoro488 Vervoeging

TLR7 (Toll-like receptor 7) is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

Toll-like receptor 7; TLR7; UNQ248/PRO285

TLR7

51284

Q9NYK1

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human TLR7, different from the related rat and mouse sequences by one amino acid.

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Flow Cytometry

Adapters, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Immunoglobulins, Immunology, Innate Immunity, Macrophage/Inflammation, Receptors, Signal Transduction, TLR Signaling, Transcription, Transmembrane

Immunogen affinity purified.

Liquid

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity) . .

1. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C.Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.Science 303: 1529-1531, 2004. 2. Hayashi, T., Gray, C. S., Chan, M., Tawatao, R., Ronacher, L., McGargill, M. A., Datta, S. K., Carson, D. A., Corr, M.Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. 3. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S.Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.Nature Immun. 3: 196-200, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

120922 MW

No cross reactivity with other proteins.

6

Toll-like receptor 7

Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. .

Belongs to the Toll-like receptor family.

Toll-like receptor 7

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.