Anti-TOM1L1 Antibody Picoband®

TOM1-like protein 1 is a protein that in humans is encoded by the TOM1L1 gene. Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome.

Boster Bio Anti-TOM1L1 Antibody Picoband® catalog # A07598-2. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16

TOM1L1

10040

O75674

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TOM1L1 recombinant protein (Position: D9-D448) .

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

ELISA, Flow Cytometry, IF, IHC, WB

Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

1. Franco, M., Furstoss, O., Simon, V., Benistant, C., Hong, W. J., Roche, S. The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Molec. Cell. Biol. 26: 1932-1947, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/12/2012. 3. Katoh, Y., Imakagura, H., Futatsumori, M., Nakayama, K. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem. Biophys. Res. Commun. 341: 143-149, 2006.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A07598-2

157578 MW

55 kDa

6

C-C motif chemokine ligand 16

Secreted.

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.