Anti-TOM20 Antilichaam Picoband® fluoro594 Vervoeging

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. Enables protein-transporting ATPase activity and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane and mitochondrial outer membrane.

Homeobox protein Hox-A5; Homeobox protein Hox-1C; HOXA5; HOX1C

TOMM20

9804

Q15388

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TOMM20 recombinant protein (Position: D25-E145) .

Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636) . Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636) . Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Flow Cytometry

Cancer, Cell Cycle, Cell Cycle Inhibitors, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, p53 Pathway, Transcription

Immunogen affinity purified.

Liquid

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

1. Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S., Endo, T., Kohda, D. Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell 100: 551-560, 2000. 2. Blesa, J. R., Prieto-Ruiz, J. A., Hernandez, J. M., Hernandez-Yago, J. NRF-2 transcription factor is required for human TOMM20 gene expression. Gene 391: 198-208, 2007. 3. Goping, I. S., Millar, D. G., Shore, G. C. Identification of the human mitochondrial protein import receptor, huMas20p: complementation of delta-mas20 in yeast. FEBS Lett. 373: 45-50, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

16 kDa

6

Homeobox A5

Nucleus.

Ran-specific GTPase-activating protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.