Anti-TOM70 Antibody Picoband® 31.0647 Vervoeging

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins.

Homer protein homolog 3; Homer-3; HOMER3

TOMM70

9868

O94826

Human

No cross-reactivity with other proteins.

E.coli-derived human TOMM70 recombinant protein (Position: N122-L608) .

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Flow Cytometry

Receptors / Channels, Synapse Marker

Immunogen affinity purified.

Liquid

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

1. Alvarez-Dolado, M., Gonzalez-Moreno, M., Valencia, A., Zenke, M., Bernal, J., Munoz, A. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. J. Neurochem. 73: 2240-2249, 1999. 2. Dutta, D., Briere, L. C., Kanca, O., Marcogliese, P. C., Walker, M. A., High, F. A., Vanderver, A., Krier, J., Carmichael, N., Callahan, C., Taft, R. J., Simons, C., Helman, G., Undiagnosed Diseases Network, Wangler, M. F., Yamamoto, S., Sweetser, D. A., Bellen, H. J. De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Hum. Molec. Genet. 29: 1568-1579, 2020. 3. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 277-286, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39836 MW

6

Homer protein homolog 3

Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Postsynaptic density of neuronal cells. .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.