Anti-TOMM34 Antibody Picoband® 31.0550 Vervoeging

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene. The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.

PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2

TOMM34

10953

Q15785

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TOMM34 recombinant protein (Position: M1-H309) .

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Flow Cytometry

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Immunogen affinity purified.

Liquid

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

1. Faou, P., Hoogenraad, N. J. Tom34: a cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import. Biochim. Biophys. Acta 1823: 348-357, 2012. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 10/8/2014. 3. Mukhopadhyay, A., Avramova, L. V., Weiner, H. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. Arch. Biochem. Biophys. 400: 97-104, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104553 MW

6

PR/SET domain 5

Nucleus.

AP-2 complex subunit beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.