Anti-TOX2 Antibody Picoband® 0,00647 Vervoeging

TOX high mobility group box family member 2, also known as TOX2, is a human gene. Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm.

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283

TOX2

84969

Q96NM4

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TOX2 recombinant protein (Position: Q41-A425) .

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.

Flow Cytometry

Complement, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Kajitani, T., Mizutani, T., Yamada, K., Yazawa, T., Sekiguchi, T., Yoshino, M., Kawata, H., Miyamoto, K. Cloning and characterization of granulosa cell high-mobility group (HMG) -box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Endocrinology 145: 2307-2318, 2004. 2. Scott, A. F. Personal Communication. Baltimore, Md. 7/3/2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

C3 and PZP like, alpha-2-macroglobulin domain containing 8

Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.