Anti-TP53 Antibody Picoband® 0,00647 Vervoeging

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

TP53

7157

P04637

Human

E.coli-derived human TP53 recombinant protein (Position: M1-D186) .

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Aaltonen, L.-M., Chen, R. W., Roth, S., Makitie, A. A., Rihkanen, H., Vaheri, A., Aaltonen, L. A. Role of TP53 P72R polymorphism in human papillomavirus associated premalignant laryngeal neoplasm. J. Med. Genet. 38: 327 only, 2001. 2. Aas, T., Borresen, A.-L., Geisler, S., Smith-Sorenson, B., Johnsen, H., Varhaug, J. E., Akslen, L. A., Lonning, P. E. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nature Med. 2: 811-814, 1996. 3. Abida, W. M., Nikolaev, A., Zhao, W., Zhang, W., Gu, W. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. J. Biol. Chem. 282: 1797-1804, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.