Anti-TP53 Antibody Picoband®

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

Boster Bio Anti-TP53 Antibody Picoband® catalog # A00001-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

TP53

7157

P04637

Human

E.coli-derived human TP53 recombinant protein (Position: M1-D186) .

WB, IHC, Flow Cytometry, ELISA

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Aaltonen, L.-M., Chen, R. W., Roth, S., Makitie, A. A., Rihkanen, H., Vaheri, A., Aaltonen, L. A. Role of TP53 P72R polymorphism in human papillomavirus associated premalignant laryngeal neoplasm. J. Med. Genet. 38: 327 only, 2001. 2. Aas, T., Borresen, A.-L., Geisler, S., Smith-Sorenson, B., Johnsen, H., Varhaug, J. E., Akslen, L. A., Lonning, P. E. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nature Med. 2: 811-814, 1996. 3. Abida, W. M., Nikolaev, A., Zhao, W., Zhang, W., Gu, W. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. J. Biol. Chem. 282: 1797-1804, 2007.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A00001-2

53 kDa

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.