Anti-TP53I13 Antibody Picoband® 31.0647 Vervoeging

TP53I13 is involved in several processes, including negative regulation of cell cycle, response to UV, and response to xenobiotic stimulus. It may act as a tumor suppressorwhich could inhibits tumor cell growth, when overexpressed.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

TP53I13

90313

Q8NBR0

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TP53I13 recombinant protein (Position: A30-Q365) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Otsuki, T. , Ota, T. , Nishikawa, T. , Hayashi, K. , & Isogai, T. . (2005) . Signal sequence and keyword trap in silico for selection of full-length human cdnas encoding secretion or membrane proteins from oligo-capped cdna libraries. Dna Research, 12 (2), 117-126. 2. Luck, K. , Kim, D. K. , Lambourne, L. , Spirohn, K. , & Calderwood, M. A. . (2020) . A reference map of the human binary protein interactome. Nature, 580 (D1) . 3. Ota, T. , Suzuki, Y. , Nishikawa, T. , Otsuki, T. , Sugiyama, T. , & Irie, R. , et al. (2004) . Complete sequencing and characterization of 21,243 full-length human cdnas. Nature Genetics.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.