Anti-TRAF5 Antibody Picoband® fluoro488 Vervoeging

TNF receptor-associated factor 5, also known as RNF84, is a protein that in humans is encoded by the TRAF5 gene. The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family. Fluorescence in situ hybridization confirmed the regional localization of human TRAF5 to chromosome 1q32.2-q32.3. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. It is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. It seems to be involved in apoptosis.

TNF receptor-associated factor 5; RING finger protein 84; TRAF5; RNF84

TRAF5

7188

O00463

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human TRAF5, different from the related mouse sequence by two amino acids.

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, TNF Superfamily

Immunogen affinity purified.

Liquid

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. .

1. Kraus, Z. J., Nakano, H., Bishop, G. A. TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc. Nat. Acad. Sci. 106: 17140-17145, 2009. 2. So, T., Salek-Ardakani, S., Nakano, H., Ware, C. F., Croft, M. TNF receptor-associated factor 5 limits the induction of Th2 immune responses. J. Immun. 172: 4292-4297, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64406 MW

No cross reactivity with other proteins.

6

TNF receptor-associated factor 5

Cytoplasm . Cytoplasm, cytosol .

Belongs to the TNF receptor-associated factor family. A subfamily.

TNF receptor-associated factor 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.