Anti-Transcriptiefactor SOX-2 SOX2 Antibody Picoband® 31.0647 Vervoeging

SRY (sex determining region Y) -box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency of undifferentiated embryonic stem cells. Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This gene is mapped to 3q26.33. It is found that SOX2 can regulate OCT3/4 expression and maintains ES pluripotency through upstream transcription factors. SOX2 is identified as a lineage-survival oncogene in lung and esophageal squamous cell carcinoma. In addition to those, SOX2 has a critical role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.

Transcription factor SOX-2; SOX2

SOX2

6657

P48431

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human SOX2, different from the related mouse and rat sequence by one amino acid.

Flow Cytometry

Cell Type Marker, Developmental Biology, Domain Families, Embryogenesis, Embryonic Stem Cells, Epigenetics and Nuclear Signaling, Germ Cell Markers, Germline Stem Cells, Hlh/Leucine Zipper, Intracellular, Neural Signal Transduction, Neurogenesis, Neurology Process, Neuroscience, Reproduction, Stem Cells, Surface Molecules, Transcription

Immunogen affinity purified.

Liquid

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . .

1. Bass, A. J., Watanabe, H., Mermel, C. H., Yu, S., Perner, S., Verhaak, R. G., Kim, S. Y., Wardwell, L., Tamayo, P., Gat-Viks, I., Ramos, A. H., Woo, M. S., and 36 others. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genet. 41: 1238-1242, 2009. 2. Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A. A., Ko, M. S. H., Niwa, H. Pluripotency governed bySox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nature Cell Biol. 9: 625-635, 2007. 3. Rizzino A (2009) . Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells. Wiley Interdiscip Rev Syst Biol Med 1 (2) : 228–36.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

34310 MW

No cross reactivity with other proteins.

6

Transcription factor SOX-2

Nucleus.

Contains 1 HMG box DNA-binding domain.

Transcription factor SOX-2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.