Anti-Transglutaminase 2/TGM2 Antibody Picoband® fluoro488 Vervoeging

Tissue transglutaminase, also called TGC, is a 78-kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. By fluorescence in situ hybridization (FISH), this gene is mapped in 20q11.23. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.

Protein-glutamine gamma-glutamyltransferase 2;2.3.2.13; Tissue transglutaminase; Transglutaminase C; TG (C) ; TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2; TGM2

TGM2

7052

P21980

Human, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human TGM2, different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Apoptosis, Associated Proteins, Autoimmune, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Biology, Immune System Diseases, Immunology, Intracellular, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

1. Antonyak, M. A., Jansen, J. M., Miller, A. M., Ly, T. K., Endo, M., Cerione, R. A. Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc. Nat. Acad. Sci. 103: 18609-18614, 2006. 2. Mastroberardino, P. G., Iannicola, C., Nardacci, R., Bernassola, F., de Laurenzi, V., Melino, G., Moreno, S., Pavone, F., Oliverio, S., Fesus, L., Piacentini, M. 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ. 9: 873-880, 2002. 3. Priglinger, S. G., May, C. A., Neubauer, A. S., Alge, C. S., Schoenfeld, C.-L., Kampik, A., Welge-Lussen, U. Tissue transglutaminase as a modifying enzyme of the extracellular matrix in PVR membranes. Invest. Ophthal. Vis. Sci. 44: 355-364, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

77329 MW

No cross reactivity with other proteins.

6

Protein-glutamine gamma-glutamyltransferase 2

Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Belongs to the transglutaminase superfamily. Transglutaminase family.

Protein-glutamine gamma-glutamyltransferase 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.