Anti-TRF1/TERF1 Antibody Picoband® fluoro550 Vervoeging

Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

Angiopoietin-like protein 8 ; Betatrophin ; Lipasin ; Refeeding-induced fat and liver protein ; ANGPTL8 ; C19orf80, RIFL ; UNQ599/PRO1185

TERF1

7013

P54274

Human

No cross-reactivity with other proteins.

E.coli-derived human TRF1/TERF1 recombinant protein (Position: Q119-R341) .

Predominantly expressed in liver. Also expressed in adipose tissues. .

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577) . May be involved in the metabolic transition between fasting and refeeding: required to fatty acids to adipose tissue for storage in the fed state (By similarity) . .

1. Broccoli, D., Chong, L., Oelmann, S., Fernald, A. A., Marziliano, N., van Steensel, B., Kipling, D., Le Beau, M. M., de Lange, T. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Hum. Molec. Genet. 6: 69-76, 1997. 2. Chen, Y., Yang, Y., van Overbeek, M., Donigian, J. R., Baciu, P., de Lange, T., Lei, M. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-1096, 2008. 3. Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., de Lange, T. A human telomeric protein. Science 270: 1663-1667, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

22105 MW

6

Angiopoietin-like protein 8

Secreted .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.