Anti-TRMT2B Antibody Picoband® fluoro488 Vervoeging

This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

TRMT2B

79979

Q96GJ1

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TRMT2B recombinant protein (Position: M1-R504) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Minczuk, M. , & Powell, C. A. . Trmt2b is responsible for both trna and rrna m5u-methylation in human mitochondria. 2. Dai, W. , Li, A. , Yu, N. J. , Nguyen, T. , Leach, R. W. , & M Wühr, et al. Activity-based rna-modifying enzyme probing reveals dus3l-mediated dihydrouridylation. Nature chemical biology. 3. Daakour, S. , Hajingabo, L. J. , Kerselidou, D. , Devresse, A. , Kettmann, R. , & Simonis, N. , et al. (2016) . Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals ext-1 tumor suppressor as a notch1 and fbwx7 common interactor. BMC Cancer.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.