Anti-TRMT6 Antibody Picoband® 31.0550 Vervoeging

This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants.

Follicular dendritic cell secreted peptide; FDC secreted protein; FDC-SP; FDCSP; C4orf7; UNQ733/PRO1419

TRMT6

51605

Q9UJA5

Human

No cross-reactivity with other proteins

E.coli-derived human TRMT6 recombinant protein (Position: E6-K489) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Immunology, Secreted Molecules

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Wang, Y. , Huang, Q. , Deng, T. , Li, B. H. , & Ren, X. Q. . (2019) . Clinical significance of trmt6 in hepatocellular carcinoma: a bioinformatics-based study. Medical Science Monitor, 25, 3894-3901. 2. Finermoore, J. , Czudnochowski, N. , O'Connell, J. D. , Wang, A. L. , & Stroud, R. M. . (2015) . Crystal structure of the human trna m1a58 methyltransferase–trna3lys complex: refolding of substrate trna allows access to the methylation target. Journal of Molecular Biology, 427 (24), 3862-3876. 3. Wang, Y. , Wang, J. , Li, X. , Xiong, X. , Wang, J. , & Zhou, Z. , et al. N 1-methyladenosine methylation in trna drives liver tumourigenesis by regulating cholesterol metabolism. Nature communications, 12 (1), 6314.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

9700 MW

6

Follicular dendritic cell secreted peptide

Secreted.

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.