Anti-TRPC3 Antibody Picoband® fluoro488 Vervoeging

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3; TRPC3; TRP3

TRPC3

7222

Q13507

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human TRPC3, identical to the related rat and mouse sequences.

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Flow Cytometry

Calcium Channels, Calcium Signaling, Cardiovascular, Hypertrophy, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vasculature

Immunogen affinity purified.

Liquid

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. .

1. Fusco FR, Martorana A, Giampà C, De March Z, Vacca F, Tozzi A, Longone P, Piccirilli S, Paolucci S, Sancesario G, Mercuri NB, Bernardi G (July 2004) . Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes. Neuroscience Letters. 365 (2) : 137–42. 2. Li HS, Xu XZ, Montell C (1999) . Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron. 24 (1) : 261–73. 3. Zhou FW, Matta SG, Zhou FM (January 2008) . Constitutively active TRPC3 channels regulate basal ganglia output neurons. The Journal of Neuroscience. 28 (2) : 473–82.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

96009 MW

No cross reactivity with other proteins.

6

Short transient receptor potential channel 3

Membrane; Multi-pass membrane protein.

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.

Short transient receptor potential channel 3 (TrpC3)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.