Anti-TRPV4 Antibody Picoband® 0,00647 Vervoeging

Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene. This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.

TRPV4

59341

Q9HBA0

Human, Mouse, Rat

E.coli-derived human TRPV4 recombinant protein (Position: R64-D408) . Human TRPV4 shares 97.4% amino acid (aa) sequence identity with both mouse and rat TRPV4.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Aharoni, S., Harlalka, G., Offiah, A., Shuper, A., Crosby, A. H., McEntagart, M. Striking phenotypic variability in familial TRPV4-axonal neuropathy spectrum disorder. Am. J. Med. Genet. 155A: 3153-3156, 2011. 2. Amor, D. J., Tudball, C., Gardner, R. J. M., Lamande, S. R., Bateman, J. F., Savarirayan, R. Familial digital arthropathy-brachydactyly. Am. J. Med. Genet. 108: 235-240, 2002. 3. Andreucci, E., Aftimos, S., Alcausin, M., Haan, E., Hunter, W., Kannu, P., Kerr, B., McGillivray, G., McKinlay Gardner, R. J., Patricelli, M. G., Sillence, D., Thompson, E., Zacharin, M., Zankl, A., Lamande, S. R., Savarirayan, R. TRPV4 related skeletal dysplasias: a phenotypic spectrum highlighted by clinical, radiographic, and molecular studies in 21 new families. Orphanet J. Rare Dis. 6: 37, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

98 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.