Anti-Tryptofaan Hydroxylase/TPH1 Antibody Picoband® fluoro550 Vervoeging

Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene. This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; TPH1; TPH; TPRH; TRPH

TPH1

7166

P17752

Human

No cross-reactivity with other proteins.

E.coli-derived human Tryptophan Hydroxylase/TPH1 recombinant protein (Position: K383-I444) .

Isoform 2 seems to be less widely expressed than isoform 1.

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Cancer, Cancer Metabolism, Endocrine Metabolism, Energy Metabolism, Energy Transfer Pathways, Hormone Biosynthesis, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuroscience, Neurotransmitter, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

1. Entrez Gene: TPH1 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) . 2. New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ (1998) . Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. Am. J. Med. Genet. 81 (1) : 13–7.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Tryptophan hydroxylase 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.