Anti-TSPY1/2/3/4 Antibody Picoband® fluoro550 Vervoeging

Testis-specific Y-encoded protein 1/2/3/4 is a protein that in humans is encoded by the TSPY1/2/3/4 gene. The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants.

Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1; TACC1; KIAA1103

TSPY1/2/3/4

7258/64591/728137/728395

Q01534/A6NKD2/P0CV98/P0CV99

Human

No cross-reactivity with other proteins.

E.coli-derived human TSPY1/2/3/4 recombinant protein (Position: R16-R247) .

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .

Flow Cytometry

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

1. Arnemann, J., Epplen, J. T., Cooke, H. J., Sauermann, U., Engel, W., Schmidtke, J. A human Y-chromosomal DNA sequence expressed in testicular tissue. Nucleic Acids Res. 15: 8713-8724, 1987. 2. Arnemann, J., Jakubiczka, S., Thuring, S., Schmidtke, J. Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. Genomics 11: 108-114, 1991. 3. Guttenbach, M., Muller, U., Schmid, M. A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes. Genomics 13: 363-367, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

87794 MW

6

Transforming acidic coiled-coil-containing protein 1

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .

Transforming acidic coiled-coil-containing protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.