Anti-TTLL12 Antibody Picoband® fluoro488 Vervoeging

Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm.

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

TTLL12

23170

Q14166

Human

No cross-reactivity with other proteins.

E.coli-derived human TTLL12 recombinant protein (Position: E8-Q634) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

1. Brants, J., Semenchenko, K., Wasylyk, C., Robert, A., Carles, A., Zambrano, A., Pradeau-Aubreton, K., Birck, C., Schalken, J. A., Poch, O., de Mey, J., Wasylyk, B. Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS One 7: e51258, 2012. 2. Gross, M. B. Personal Communication. Baltimore, Md. 6/28/2021. 3. Ju, L.-G., Zhu, Y., Lei, P.-J., Yan, D., Zhu, K., Wang, X., Li, Q.-L., Li, X.-J., Chen, J.-W., Li, L.-Y., Wu, M. TTLL12 inhibits the activation of cellular antiviral signaling through interaction with VISA/MAVS. J. Immun. 198: 1274-1284, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

DAP3 binding cell death enhancer 1

Mitochondrion.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.