Anti-TTLL2 Antibody Picoband®

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to be active in cilium.

Boster Bio Anti-TTLL2 Antibody Picoband® catalog # A15891. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

TTLL2

83887

Q9BWV7

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TTLL2 recombinant protein (Position: A24-E582) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

ELISA, IF, IHC, WB

Cell Biology

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Ribeiro, M. , Angelini, L. , Roblesribeiro, P. G. , Stelmach, R. , Santos, U. D. P. , & Terrafilho, M. . (2000) . Characterization of the human tubulin tyrosine ligase-like 1 gene (ttll1) mapping to 22q13.1. Gene, 257 (1), 109-117. 2. Faust, T. B. , Yang, L. , Bacon, C. W. , Jang, G. M. , & Frankel, A. D. . (2018) . The hiv-1 tat protein recruits a ubiquitin ligase to reorganize the 7sk snrnp for transcriptional activation. Elife, 7. 3. Ota, T. , Suzuki, Y. , Nishikawa, T. , Otsuki, T. , Sugiyama, T. , & Irie, R. , et al. (2004) . Complete sequencing and characterization of 21,243 full-length human cdnas. Nature Genetics.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A15891

24145 MW

70 kDa

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.