Anti-TTLL2 Antibody Picoband® fluoro488 Vervoeging

Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to be active in cilium.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

TTLL2

83887

Q9BWV7

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TTLL2 recombinant protein (Position: A24-E582) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Ribeiro, M. , Angelini, L. , Roblesribeiro, P. G. , Stelmach, R. , Santos, U. D. P. , & Terrafilho, M. . (2000) . Characterization of the human tubulin tyrosine ligase-like 1 gene (ttll1) mapping to 22q13.1. Gene, 257 (1), 109-117. 2. Faust, T. B. , Yang, L. , Bacon, C. W. , Jang, G. M. , & Frankel, A. D. . (2018) . The hiv-1 tat protein recruits a ubiquitin ligase to reorganize the 7sk snrnp for transcriptional activation. Elife, 7. 3. Ota, T. , Suzuki, Y. , Nishikawa, T. , Otsuki, T. , Sugiyama, T. , & Irie, R. , et al. (2004) . Complete sequencing and characterization of 21,243 full-length human cdnas. Nature Genetics.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.