Anti-Tuberine TSC2 Konijn Monoklonale Antilichaam

Boster Bio Anti-Tuberin TSC2 Rabbit Monoclonal Antibody catalog # M00229. Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

TSC2

7249

P49815

Human, Mouse, Rat

A synthesized peptide derived from human Tuberin

Clone: EGD-20

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

WB, IHC, Flow Cytometry

Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription, Transcription Factors

Affinity-chromatography

0.5mg/ml

Liquid

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00229

200608 MW

100-110 kDa

Tuberin

Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

P2X purinoceptor 1

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.