Anti-α-Tubuline (C-terminus) Antilichaam

Microtubules (MTs) are cytoskeletal elements that play an essential role in cell division and cytoplasmic organization. MTs are dynamic polymers of a/β-Tubulin heterodimers. At least two populations of MTs, called dynamic and stable according to their rates of turnover, are readily distinguishable in cells. The proteins associated with MTs (MAPs) are among the best-known factors that regulate MT dynamics and stability. In addition, a variety of different post-translational modifications may also regulate MT dynamics and stability. Phosphorylation is one of these modifications and it can occur on serine, threonine, and tyrosine residues in α- and β-Tubulin isoforms. Multiple kinases can phosphorylate Ser-444 at the C-terminus of βIII-Tubulin in vitro, and unphosphorylated Ser-444 may be an early marker for cells of neuronal lineage. Cdk1 can phosphorylate Ser-172 in β-Tubulin during mitosis and this may impair tubulin incorporation into microtubules. In α-tubulin, PKC can phosphorylate Ser-165 leading to increased cell motility in human breast cells.

Our α-Tubulin (C-terminus) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat α-Tubulin (C-terminus) and is protein a purified. It is great for use in ELISA, WB, ICC, IHC, IP.

Our α-Tubulin (C-terminus) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat α-Tubulin (C-terminus) and is Protein A purified. It is great for use in WB, ICC, IHC, IP.

Alpha Tubulin, Tubulin A1C

TUBA1

P02552

Human, Mouse, and Rat

Clone DM1A was generated from purified chick brain tubulin. The antibody recognizes an epitope within the C-terminal end of α-tubulin isoforms. The epitope is highly conserved in α-tubulin isoforms from most vertebrate species.

α-Tubulin (C-terminus)

DM1A

Unconjugated

ELISA, WB, ICC, IHC, IP

Cell Markers, Cytoskeletal Markers, Cell Signaling, Cytoskeletal Regulation

Protein A Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

55

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein A purified culture supernatant.

1:500

The antibody detects a 55 kDa* protein corresponding to the molecular mass of α-Tubulin on SDS-PAGE immunoblots of human, rat, and mouse cells and tissues.

1:200

Western blots performed on each lot.

Mouse

Liquid

IgG1

Chicken

Quality Control: WB

AB_10703566