Anti-TXNDC3/NME8 Antibody Picoband® fluoro488 Vervoeging

This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.

NME8; SPTRX2; TXNDC3; Thioredoxin domain-containing protein 3; NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2

NME8

51314

Q8N427

Human, Rat

No cross-reactivity with other proteins

E.coli-derived human TXNDC3/NME8 recombinant protein (Position: M1-H446) . Human TXNDC3/NME8 shares 63% and 61.2% amino acid (aa) sequence identity with mouse and rat TXNDC3/NME8, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Duriez, B., Duquesnoy, P., Escudier, E., Bridoux, A.-M., Escalier, D., Rayet, I., Marcos, E., Vojtek, A.-M., Bercher, J.-F., Amselem, S. A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. Proc. Nat. Acad. Sci. 104: 3336-3341, 2007. Note: Erratum: Proc. Nat. Acad. Sci. 104: 6490 only, 2007. 2. Sadek, C. M., Damdimopoulos, A. E., Pelto-Huikko, M., Gustafsson, J.-A., Spyrou, G., Miranda-Vizuete, A. Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells. Genes Cells 6: 1077-1090, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67 kDa

6

NME/NM23 family member 8

Thioredoxin domain-containing protein 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.