Anti-TXNRD2 Antibody Picoband® fluoro488 Vervoeging

TXNRD2 (Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are selenocysteine (sec) -containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing power of NADPH. By STS analysis and genomic sequence analysis, respectively, Miranda-Vizuete et al. (1999) and Sun et al. (1999) mapped the TXNRD2 gene to chromosome 22q11.2. Miranda-Vizuete et al. (1999) mapped the mouse gene to chromosome 16. Gasdaska et al. (1999) showed that TXNRD2 was a thioredoxin reductase that could ly reduce proteins such as insulin.

Thioredoxin reductase 2, mitochondrial;1.8.1.9; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3; TXNRD2; KIAA1652, TRXR2

TXNRD2

10587

Q9NNW7

Human, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human TXNRD2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. .

Flow Cytometry

Cell Biology, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism

Immunogen affinity purified.

Liquid

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.

1. Gasdaska, P. Y., Berggren, M. M., Berry, M. J., Powis, G.Cloning, sequencing, and functional expression of a novel human thioredoxin reductase.FEBS Lett. 442: 105-111, 1999. 2. Miranda-Vizuete, A., Damdimopoulos, A. E., Pedrajas, J. R., Gustafsson, J.-A., Spyrou, G.Human mitochondrial thioredoxin reductase: cDNA cloning, expression, and genomic organization.Europ. J. Biochem. 261: 405-412, 1999. 3. Sun, Q.-A., Wu, Y., Zappacosta, F., Jeang, K.-T., Lee, B. J., Hatfield, D. L., Gladyshev, V. N.Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.J. Biol. Chem. 274: 24522-24530, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

56507 MW

No cross reactivity with other proteins.

6

Thioredoxin reductase 2, mitochondrial

Mitochondrion .

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Thioredoxin reductase 2, mitochondrial

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.