Anti-tyrosine Kinasereceptor A (TrkA) Antilichaam

TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer (Reference: www.uniprot.com) .

Our Anti-Tyrosine Kinase Receptor A (TrkA) mouse monoclonal primary antibody detects human, mouse, other mammals (predicted), and rat Tyrosine Kinase Receptor A (TrkA), and is igg. It is validated for use in ICC, WB.

Our Anti-Tyrosine Kinase Receptor A (TrkA) mouse monoclonal primary antibody detects human, mouse, other mammals (predicted), and rat Tyrosine Kinase Receptor A (TrkA), and is IgG. It is validated for use in ICC, WB.

Tropomyosin-related kinase receptor; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1 transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK

P04629

Human, Mouse, Other Mammals (Predicted), and Rat

A synthetic peptide from the intracellular cytoplasmic domain of human TrkA (C-HGPDAKLLAGGE, aa: 604-615) has been used as the immunogen.

Tyrosine Kinase Receptor A (TrkA)

BS292

Unconjugated

ICC, WB

IgG

Lyophilized from PBS, pH 7.4, containing 3% trehalose without preservatives.

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Final buffer contains no preservatives.After reconstitution divide into aliquots and store at -20°C for a higher stability. Antibody contains no preservatives. Store at 2-8°C with an appropriate antibacterial agent. Use sterile methods. Highest purity Glycerol (1:1) may be added for an additional stability when stored at refrigerated or freezing temperatures. Avoid repetitive freeze/thaw cycles.

Protein G purified mouse immunoglobulin

1-3 μg/mL

TrkA. Does not cross-react with TrkB or TrkC. Reacts with human TrkA. Known to cross-react with TrkA from rat and mouse. Expected to cross-react with other mammalian species based on peptide antigen sequence similarity.

1-2 μg/mL

Mouse

Lyophilized

IgG3, kappa

Human