Anti-UBA5 Antibody Picoband® 31.0550 Vervoeging

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene. This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1.

Rho-related GTP-binding protein Rho6; Rho family GTPase 1; Rnd1; RND1; RHO6

UBA5

79876

Q9GZZ9

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human UBA5 recombinant protein (Position: R37-D389) .

Mostly expressed in brain and liver.

Flow Cytometry

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins

Immunogen affinity purified.

Liquid

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. .

1. Colin, E., Daniel, J., Ziegler, A., Wakim, J., Scrivo, A., Haack, T. B., Khiati, S., Denomme, A.-S., Amati-Bonneau, P., Charif, M., Procaccio, V., Reynier, P., and 19 others. Biallelic variants in UBA5 reveal that disruption of the UFM1 cascade can result in early-onset encephalopathy. Am. J. Hum. Genet. 99: 695-703, 2016. 2. Dou, T., Gu, S., Liu, J., Chen, F., Zeng, L., Guo, L., Xie, Y., Mao, Y. Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1. Molec. Biol. Rep. 32: 265-271, 2005. 3. Duan, R., Shi, Y., Yu, L., Zhang, G., Li, J., Lin, Y., Guo, J., Wang, J., Shen, L., Jiang, H., Wang, G., Tang, B. UBA5 mutations cause a new form of autosomal recessive cerebellar ataxia. PLoS One 11: e0149039, 2016. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26056 MW

6

Rho-related GTP-binding protein Rho6

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .

AP-2 complex subunit mu

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.