Anti-UBQLN4/A1Up Antilichaam

Boster Bio Anti-UBQLN4/A1Up Antibody (Catalog# A08887) . Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse.

UBQLN4; C1orf6; CIP75; UBIN; Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75

UBQLN4

Q9NRR5

Human, Mouse

A peptide derived from human UBQLN4. Immunogen sequence location: 201 - 250

Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

WB, IHC, ICC, IF, ELISA

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ub-Like Proteins

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Liquid

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS) . Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6) . Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity) . Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) .

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08887

63853 MW

Ubiquilin-4

Nucleus. Cytoplasm. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm.

Rabbit IgG

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.