Anti-UBXN8 Antibody Picoband® fluoro594 Vervoeging

P97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

UBXN8

7993

O00124

Human

No cross-reactivity with other proteins

E.coli-derived human UBXN8 recombinant protein (Position: N149-N270) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Yamabe, Y., Ichikawa, K., Sugawara, K., Imamura, O., Shimamoto, A., Suzuki, N., Tokutake, Y., Goto, M., Sugawara, M., Furuichi, Y. Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12. Genomics 39: 198-204, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.