Anti-UFD1L Antilichaam

Boster Bio Anti-UFD1L Antibody catalog # A32358. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.

Ubiquitin recognition factor in ER-associated degradation protein 1

UFD1

Q92890

Human, Mouse

Recombinant fusion protein of human UFD1L (NP_005650.2) .

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

WB, ICC, IF

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

1 mg/mL

Liquid

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity) . Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729) .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A32358

34500 MW

Ubiquitin recognition factor in ER-associated degradation protein 1

Nucleus

Ubiquitin recognition factor in ER-associated degradation protein 1

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2