Anti-UHRF1 Antibody Picoband® 3100550 Vervoeging

Ubiquitin-like, containing PHD and RING finger domains, 1 is a protein which in humans is encoded by the UHRF1 gene. This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT; TNNT2

UHRF1

29128

Q96T88

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human UHRF1 recombinant protein (Position: K592-R793) .

Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

Flow Cytometry

Actin, etc., Cardiovascular, Contractility, Cytoskeleton, Cytoskeleton/ECM, Mesenchymal Stem Cells, Microfilaments, Signal Transduction, Stem Cells

Immunogen affinity purified.

Liquid

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

1. Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1. 2. Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000) .ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression.Cancer Research 60 (1) : 121–8.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Troponin T2, cardiac type

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.