Anti-uPA-receptor/U-PAR/PLAUR Antilichaam Picoband® 31.0550 Vervoeging

PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

Urokinase plasminogen activator surface receptor; U-PAR; Monocyte activation antigen Mo3; uPAR; CD87; Plaur; MO3; UPAR

PLAUR

5329

Q03405

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human uPA Receptor/U-PAR/PLAUR recombinant protein (Position: E128-R167) .

Expressed in neurons of the rolandic area of the brain (at protein level) . Expressed in the brain.

Flow Cytometry

Immunology, Cancer, Cardiovascular, Cell Type Markers, Extracellular Matrix, Tumor Biomarkers, Invasion/Microenvironment, Receptors

Immunogen affinity purified.

Liquid

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

1. Borglum, A., Anette, B., Roldan, A. L., Blasi, F., Bolund, L., Kruse, T. A. Assignment of the gene for urokinase-type plasminogen activator receptor to chromosome 19q13. 2. Borglum, A. D., Byskov, A., Ragno, P., Roldan, A. L., Tripputi, P., Cassani, G., Dano, K., Blasi, F., Bolund, L., Kruse, T. A. Assignment of the urokinase-type plasminogen activator receptor gene (PLAUR) to chromosome 19q13.1-q13.2. Am. J. Hum. Genet. 50: 492-497, 1992. 3. Llinas P, Le Du MH, Gårdsvoll H, et al. (May 2005) . Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Plasminogen activator, urokinase receptor

Cell membrane. invadopodium membrane. GPI-anchor. Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.