Anti-USP22 Antibody Picoband® fluoro488 Vervoeging

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17. Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex.

Kallikrein-2; Glandular kallikrein-1; hGK-1; Tissue kallikrein-2; KLK2

USP22

23326

Q9UPT9

Human, Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the N-terminus of human USP22, which shares 89.5% amino acid (aa) sequence identity with mouse USP22.

Flow Cytometry

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

1. Cai, Z., Zhang, M.-X., Tang, Z., Zhang, Q., Ye, J., Xiong, T.-C., Zhang, Z.-D., Zhong, B. USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. J. Exp. Med. 217: e20191174, 2020. Note: Electronic Article. 2. Cortez, J. T., Montauti, E., Shifrut, E., Gatchalian, J., Zhang, Y., Shaked, O., Xu, Y., Roth, T. L., Simeonov, D. R., Zhang, Y., Chen, S., Li, Z., and 13 others. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature 582: 416-420, 2020. 3. Gross, M. B. Personal Communication. Baltimore, Md. 9/3/2020.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Kallikrein-related peptidase 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.