Anti-USP44 Antilichaam

Boster Bio Anti-USP44 Antibody catalog # A08401. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

Ubiquitin carboxyl-terminal hydrolase 44;3.4.19.12; Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44; USP44

USP44

Q9H0E7

Human, Mouse

The antiserum was produced against synthesized peptide derived from human USP44. AA range:211-260

Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia. .

WB, ELISA

Immunogen affinity purified

1 mg/mL

Liquid

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) . Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08401

81185 MW

Ubiquitin carboxyl-terminal hydrolase 44

Nucleus . Peaks in interphase, with relatively low levels maintained throughout mitosis. .

IgG

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.