Anti-Vegfc Antibody Picoband® fluoro550 Vervoeging

Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34. Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of angiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lymphangiogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog (s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C) .

Tyrosine aminotransferase; TAT;2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase; TAT

Vegfc

22341

P97953

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse Vegfc recombinant protein (Position: A108-R223) .

Flow Cytometry

Antiviral Signaling,2339, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Microbiology

Immunogen affinity purified.

Liquid

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro) . Has much lower affinity and transaminase activity towards phenylalanine. .

1. Balboa-Beltran, E., Fernandez-Seara, M. J., Perez-Munuzuri, A., Lago, R., Garcia-Magan, C., Couce, M. L., Sobrino, B., Amigo, J., Carracedo, A., Barros, F. A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease. J. Med. Genet. 51: 475-478, 2014. Note: Erratum: J. Med. Genet. 52: 216 only, 2015. 2. Gordon, K., Schulte, D., Brice, G., Simpson, M. A., Roukens, M. G., van Impel, A., Connell, F., Kalidas, K., Jeffery, S., Mortimer, P. S., Mansour, S., Schulte-Merker, S., Ostergaard, P. Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant Milroy-like primary lymphedema. Circ. Res. 112: 956-960, 2013. 3. Hung, C. J., Ginzinger, D. G., Zarnegar, R., Kanauchi, H., Wong, M. G., Kebebew, E., Clark, O. H., Duh, Q.-Y. Expression of vascular endothelial growth factor-C in benign and malignant thyroid tumors. J. Clin. Endocr. Metab. 88: 3694-3699, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

50399 MW

6

Tyrosine aminotransferase

Cell membrane.

Tyrosine aminotransferase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.