Anti-VEGFR-3 (N-terminus) Antilichaam

Vascular endothelial growth factor receptor-2 (VEGFR-2/Flk-1/KDR) is the primary receptor for VEGF in endothelial cells. Other VEGFR family members, VEGFR-1 (Flt-1) and VEGFR-3 (Flt-4), can also transduce the intracellular signals of VEGF. However, the role of VEGFR-1 is observed mainly during embryonic angiogenesis and VEGFR-3 signaling may be restricted to specific types of endothelial cells. Major autophosphorylation sites of VEGFR-2 are located in the kinase insert domain (Tyr-951/996) and in the tyrosine kinase catalytic domain (Tyr-1054/1059) . Other sites, Tyr-1175 and Tyr-1212 provide docking sites for downstream signaling molecules. Activation of VEGFR-2 also phosphorylates Tyr-801, leading to PI3-kinase-Akt activation and increases in endothelial nitric oxide synthase activity. Phosphorylation of mutliple sites in VEGFR-2 is required for downstream activation of several signaling pathways that control proliferation, chemotaxis, and sprouting during angiogenesis.

Our VEGFR-3 (N-terminus) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, rat VEGFR-3 (N-terminus) and is antigen affinity purified. It is great for use in ELISA, WB.

Our VEGFR-3 (N-terminus) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, rat VEGFR-3 (N-terminus) and is antigen affinity purified. It is great for use in WB.

FLT-4, Vascular endothelial growth factor receptor 3

FLT4

P35916

Human, Rat

A synthetic peptide (coupled to carrier protein) corresponding to amino acids from the N-terminal region of human VEGFR-3. This sequence has two amino acid differences from rat VEGFR-3, and five amino acid differences from mouse VEGFR-3.

VEGFR-3 (N-terminus)

Unconjugated

ELISA, WB

Cardiovascular, Cell Signaling, Growth Factor Signaling, Oncoproteins

Antigen Affinity Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

170

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Affinity purified rabbit serum

1:1000

The antibody detects a 170 kDa* band corresponding to VEGFR-3 in western blots of human endothelial and K-562 cells, and shows strong reactivity to recombinant human VEGFR-3, but not VEGFR-1 or VEGFR-2.

Western blots performed on each lot.

Rabbit

Liquid

IgG

Human

Quality Control: WB

AB_2105111