Anti-VPS36 Antibody Picoband® 31.0550 Vervoeging

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene. This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II) . This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II.

Protein SOX-15; Protein SOX-12; Protein SOX-20; SOX15; SOX12; SOX20; SOX26; SOX27

VPS36

51028

Q86VN1

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human VPS36 recombinant protein (Position: M1-S386) .

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Flow Cytometry

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Liquid

Binds to the 5'-AACAAT-3' sequence.

1. Alam, S. L., Langelier, C., Whitby, F. G., Koirala, S., Robinson, H., Hill, C. P., Sundquist, W. I. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nature Struct. Biol. 13: 1029-1030, 2006. 2. Kamura, T., Burian, D., Khalili, H., Schmidt, S. L., Sato, S., Liu, W.-J., Conrad, M. N., Conaway, R. C., Conaway, J. W., Shilatifard, A. Cloning and characterization of ELL-associated proteins EAP45 and EAP20: a role for yeast EAP-like proteins in regulation of gene expression by glucose. J. Biol. Chem. 276: 16528-16533, 2001. 3. Slagsvold, T., Aasland, R., Hirano, S., Bache, K. G., Raiborg, C., Trambaiolo, D., Wakatsuki, S., Stenmark, H. Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J. Biol. Chem. 280: 19600-19606, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

SRY-box 15

Nucleus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.