Anti-WASP / N-WASP Antilichaam

Members of the Wiskott-Aldrich sydrome protein (WASP) family regulate the formation of actin-based cell structures in many cell types. These proteins contain C-terminal actin-binding domains that can stimulate actin polymerization. In addition, these proteins bind the ARP2/3 complex, which can nucleate actin polymerization at sites that lead to branched actin structures. WASP is expressed primarily in hematopoietic cells, while its homolog N-WASP is widely expressed. These proteins have 48% identity in human with the highest homology in the functional regions of these proteins. Serine and tyrosine phosphorylation regulates the activity of both proteins. WASP is observed as a 63 kDa protein in hematopoietic cells, while N-WASP is observed as a 65 kDa in many tissues, especially brain.

Our WASP / N-WASP rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat WASP / N-WASP and is antigen affinity purified. It is great for use in ELISA, WB, ICC.

Our WASP / N-WASP rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat WASP / N-WASP and is antigen affinity purified. It is great for use in WB, ICC.

Neural Wiskott-Aldrich syndrome protein, WASL, WASP

WASL

O00401

Human, Mouse, and Rat

A synthetic peptide (coupled to KLH) corresponding to a region near the C-terminus of human WASP. This sequence is highly homologous with a similar region in human N-WASP.

WASP / N-WASP

Unconjugated

ELISA, WB, ICC

Cell Markers, Cytoskeletal Markers, Cell Signaling, Cytoskeletal Regulation

Antigen Affinity Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

63

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Affinity purified rabbit serum

1:1000

This antibody detects a 63 kDa* protein corresponding to the molecular mass of WASP on SDS-PAGE immunoblots of Jurkat cell lysate. In rat brain, A431, and SKN-SH cells, this antibody detects a 65 kDa* protein corresponding to the molecular mass of N-WASP.

1:100

Western blots performed on each lot.

Rabbit

Liquid

IgG

Human

Quality Control: WB

AB_715260